Statistical reanalysis of natural products reveals increasing chemical diversity
نویسندگان
چکیده
منابع مشابه
Statistical reanalysis of natural products reveals increasing chemical diversity.
In their retrospective analysis of natural product (NP) discovery since the 1940s, Pye et al. (1) observe a gradual decline in the proportion of NPs discovered each year with low similarity to previously known compounds [defined by maximum Tanimoto coefficient (Tc) < 0.4]. Additionally, the authors report that the median maximum Tc for all NPs discovered in a given year has plateaued since the ...
متن کاملNatural products--a simple model to explain chemical diversity.
A simple evolutionary model is presented which explains why organisms produce so many natural products, why so many have low biological activity, why enzymes involved in natural product synthesis have the properties they do and why natural product metabolism is shaped as it is.
متن کاملThe Impact of Studies of Natural Products on Chemical Industry
I regard it as a great honour to be able to speak to you at this opening ceremony of the Symposium on The Chemistry of Natural Products. I would like to express my sincere and heartfelt thanks to the Australian Academy of Science, and especially to the Organizing Committee, for the invitation which they extended to me and which I accepted with great pleasure. This is my first visit to Australia...
متن کاملIncreasing diversity: Natural language measures for software fault prediction
While challenging, the ability to predict faulty modules of a program is valuable to a software project because it can reduce the cost of software development, as well as software maintenance and evolution. Three language-processing based measures are introduced and applied to the problem of fault prediction. The first measure is based on the usage of natural language in a program’s identifiers...
متن کاملBiosynthesis and chemical synthesis of presilphiperfolanol natural products.
Presilphiperfolanols constitute a family of biosynthetically important sesquiterpenes which can rearrange to diverse sesquiterpenoid skeletons. While the origin of these natural products can be traced to simple linear terpene precursors, the details of the enzymatic cyclization mechanism that forms the stereochemically dense tricyclic skeleton has required extensive biochemical, computational, ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2017
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.1708560114